NexoBrid®
“美迪文”清創凝膠藥
兼具清創及保護作用的創新燒燙傷清創方法
產品資訊 Detail INfo
- 一種具有選擇性、低侵入性的酵素清創療法
- 為植萃成分，富含鳳梨酵素的蛋白水解酶濃縮物
- 適用於去除成人深二度和三度燒燙傷的焦痂。每次施用傷口面積不能超過15%TBSA
- 本產品僅能由燒傷中心受過相關專業訓練之醫療專業人員使用，使用前應詳閱使用說明（衛部藥輸字第028069號）
- 使用流程圖（參考）：
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- NexoBrid®: 原廠官方網站
- NexoBrid®: 產品介紹影片
- Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: European consensus guidelines update. Hirche C, Kreken Almeland S, Dheansa B, Fuchs P, Governa M, Hoeksema H, Korzeniowski T, Lumenta DB, Marinescu S, Martinez-Mendez JR, Plock JA, Sander F, Ziegler B, Kneser U. Burns. 2020 Mar 30. pii: S0305-4179(19)30897-6. doi: 10.1016/j.burns.2020.03.002. [Epub ahead of print]
- The enzymatic debridement for the treatment of burns of in-determinate depth. Bernagozzi F, Orlandi C, Purpura V, Morselli PG, Melandri D. J Burn Care Res. 2020 Mar 30. pii: iraa051. doi: 10.1093/jbcr/iraa051. [Epub ahead of print]
- Feasibility and safety of enzymatic debridement for the prevention of operative escharotomy in circumferential deep burns of the distal upper extremity. Fischer S, Haug V, Diehm Y, Rhodius P, Cordts T, Schmidt VJ, Kotsougiani D, Horter J, Kneser U, Hirche C. Surgery. 2019 Jan 21. pii: S0039-6060(18)30799-2.
- Time to start putting down the knife: A systematic review of burns excision tools of randomised and non-randomised trials. Edmondson SJ, Ali Jumabhoy I, Murray A. Burns. 2018 Nov;44(7):1721-1737.
- An Overview of the Use of Bromelain-Based Enzymatic Debridement (Nexobrid®) in Deep Partial and Full Thickness Burns: Appraising the Evidence. Loo YL, Goh BKL, Jeffery S. J Burn Care Res. 2018 Oct 23;39(6):932-938.
- The entity of thermal-crush-avulsion hand injury (hot-press roller burns) treated with fast acting debriding enzymes (nexobrid): literature review and report of first case. Di Castri A, Quarta L, Mataro I, Riccardi F, Pezone G, Giordano L, Shoham Y, Rosenberg L, Caleffi E. Ann Burns Fire Disasters. 2018 Mar 31;31(1):31.
- Eschar removal by bromelain based enzymatic debridement (Nexobrid ®) in burns: An European consensus. Hirche C, Citterio A, Hoeksema H, Koller J, Lehner M, Martinez JR, et al. Burns. 2017 Dec;43(8):1640-1653.
- Enzymatic debridement of deeply burned faces: Healing and early scarring based on tissue preservation compared to traditional surgical debridement. Schulz A, Fuchs PC, Rothermundt I, Hoffmann A, Rosenberg L, Shoham Y, Oberländer H, Schiefer J. Burns. 2017 Sep;43(6):1233-1243.
- Bromelain-based enzymatic debridement and minimal invasive modality (mim) care of deeply burned hands. Krieger Y, Rubin G, Schulz A, Rosenberg N, Levi A, Singer AJ, Rosenberg L, Shoham Y. Ann Burns Fire Disasters. 2017 Sep 30;30(3):198-204.
- Enzymatic debridement for the treatment of severely burned upper extremities - early single center experiences. Cordts T, Horter J, Vogelpohl J, Kremer T, Kneser U, Hernekamp JF. BMC Dermatol. 2016 Jun 24;16(1):8.
- Minimally invasive burn care: a review of seven clinical studies of rapid and selective debridement using a bromelain-based debriding enzyme (Nexobrid®). Rosenberg L, Shoham Y, Krieger Y, Rubin G, Sander F, Koller J, David K, Egosi D, Ahuja R, Singer AJ. Ann Burns Fire Disasters. 2015 Dec 31;28(4):264-274.
- A novel rapid and selective enzymatic debridement agent for burn wound management: a multi-center RCT. Rosenberg L, Krieger Y, Bogdanov-Berezovski A, Silberstein E, Shoham Y, Singer AJ. Burns. 2014 May;40(3):466-74.
- Selectivity of a bromelain based enzymatic debridement agent: A porcine study. Rosenberg L, Krieger Y, Silberstein E, Arnon O, Sinelnikov IA, Bogdanov-Berezovsky A, Singer AJ. Burns. 2012 Nov;38(7):1035-1040.
- Efficacy of enzymatic debridement of deeply burned hands. Krieger Y, Bogdanov-Berezovsky A, Gurfinkel R, Silberstein E, Sagi A, Rosenberg L. Burns. 2012 Feb;38(1):108-12.
- Reepithelialization of mid-dermal porcine burns after rapid enzymatic debridement with Debrase®. Singer AJ, Taira BR, Anderson R, McClain SA, Rosenberg L. J Burn Care Res. 2011 Nov-Dec;32(6):647-53.
- The effects of rapid enzymatic debridement of deep partial-thickness burns with Debrase on wound reepithelialization in swine. Singer AJ, Taira BR, Anderson R, McClain SA, Rosenberg L. J Burn Care Res. 2010 Sep-Oct;31(5):795-802.